Senior Principal Scientist
Computational Biology & Translation
Discovery Oncology · Genentech
I lead an interdisciplinary Cancer Dependencies Team focused on identifying cancer vulnerabilities and biomarkers for target discovery. We develop and apply interpretable machine learning and AI architectures to multimodal genomics data.
My team develops and applies computational methods to study cancer biology and identify new therapeutic targets, spanning AI models and single-cell transcriptomics. By integrating functional and clinical genomics data, we investigate the genetic alterations and perturbations that drive cancer cell states and vulnerabilities. We also engage in target assessment and early-pipeline projects within Discovery Oncology.
Oncoforest is a set of machine learning tools for enhanced interpretability, suitable for discovery and assessment of cancer vulnerabilities — a toolkit designed for biologically interpretable prediction of viability readouts and their association with molecular context.
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Interpretable models trained in cell lines can be applied to harmonized multi-omic maps of tumours and normal tissue. This directly enables forward and reverse translation.
Predictions identify known tissue and cell-type sensitivities from therapeutic intervention, and stratify patient outcomes.
Open-source methods developed for RNA and isoform biology, covering transcript discovery and quantification, alternative splicing, and RNA duplex structure. Several remain in active use.
Transcript discovery and quantification from long reads, at single-cell, pseudo-bulk and bulk resolution.
Event-level quantification of alternative splicing from RNA-seq.
Transcriptome-wide mapping of RNA:RNA interactions in vivo.
Folding of local and long-range RNA duplexes with phylogenetic analysis.
Postdoctoral mentoring. A postdoctoral fellowship is an ideal period to develop scientific independence in hypothesis-driven research. It demands creativity to formulate new hypotheses, rigorous design of models and experiments, and a strategic vision to contextualize work within the broader literature. As a mentor, I create an environment with space for independent growth while providing the guidance and support necessary for the success and career development of a postdoctoral fellow.